Symbol
Name
ID

Was
Wiskott-Aldrich syndrome
MGI:105059

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Reduced natural killer cell activity

Increased circulating IgA level

Increased circulating IgE level

Decreased circulating total IgM

Decreased specific anti-polysaccharide antibody level

Abnormal delayed hypersensitivity skin test

Epistaxis

Gingival bleeding

Hematemesis

Melena

Joint hemorrhage

Persistent bleeding after trauma

Prolonged bleeding time

Bruising susceptibility

Purpura

Petechiae

Abnormal megakaryocyte morphology

Increased megakaryocyte colony forming unit count

Bone marrow arrest at the promyelocytic stage

Autoimmune hemolytic anemia

Anemia of inadequate production

Iron deficiency anemia

Poikilocytosis

Acanthocytosis

Eosinophilia

Neutropenia

Decreased CD4:CD8 ratio

Decreased proportion of CD4-positive helper T cells

Decreased proportion of CD8-positive T cells

Lymphopenia

Monocytopenia

Leukocytosis

Absent microvilli on the surface of peripheral blood lymphocytes

Impaired lymphocyte transformation with phytohemagglutinin

Thrombocytopenia

Congenital thrombocytopenia

Intermittent thrombocytopenia

Abnormal platelet shape

Abnormal platelet volume

Decreased mean platelet volume

Lymphoproliferative disorder

Disease(s) Associated with WAS

thrombocytopenia

Wiskott-Aldrich syndrome

X-linked severe congenital neutropenia

Mouse Phenotypes

abnormal osteoclast differentiation

abnormal B cell proliferation

decreased T cell proliferation

thymus hypoplasia

abnormal thymocyte activation

spleen hyperplasia

abnormal double-negative T cell morphology

abnormal double-positive T cell morphology

decreased double-positive T cell number

abnormal bone marrow cell morphology/development

abnormal megakaryocyte morphology

increased neutrophil cell number

abnormal mast cell morphology

thrombocytopenia

abnormal B cell number

increased germinal center B cell number

decreased mature B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased follicular B cell number

increased plasma cell number

decreased B cell number

increased B cell number

decreased NK cell number

decreased T cell number

decreased lymphocyte cell number

increased monocyte cell number

increased leukocyte cell number

abnormal dendritic cell morphology

abnormal lymphocyte morphology

increased splenocyte number

abnormal mast cell physiology

abnormal B cell physiology

increased IgA level

increased IgE level

increased IgM level

abnormal osteoclast physiology

Availability

Mouse Genotype

Was^tm1Itl/Was^tm1Itl

Was^tm1Kas/Was^tm1Kas

Was^tm1Sbs/Was^tm1Sbs

Was^tm2Itl/Was^tm2Itl

Was^tm1Itl/Y

Was^tm1Sbs/Y

Was^tm2Itl/Y

Cd79a^tm1(cre)Reth/Cd79a⁺
Was^tm1.1Ldn/Was^tm1.1Ldn (conditional)

Cd79a^tm1(cre)Reth/Cd79a⁺
Was^tm1.1Ldn/Y (conditional)

Cd79a^tm1(cre)Reth/Cd79a⁺
Was^tm1.1Ldn/Was⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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